Methods Innovation Fund 1

The following projects have been completed:

  • Searching for unpublished trials using trials registers and trials web sites and obtaining unpublished trial data and corresponding trial protocols from regulatory agencies: See MIF 2 project on the inclusion of Clinical Study Reports and other regulatory data that takes this work forward. 
  • Enhancing the acceptance and implementation of ‘Summary of findings’ tables in Cochrane Reviews:  This project has now completed. Extensive user testing and an international randomized controlled trial (RCT) with 290 participants showed an alternative format of the ‘Summary of findings’ (SoF) Table has advantages over the current format used in Cochrane Reviews. In collaboration with the GRADE Working Group developed a new format of SoF Table for therapeutic interventions and test accuracy reviews. See MIF 2 project on the development of guidance for GRADE assessments to incorporate non-randomized studies alongside randomized studies in ‘Summary of findings’ tables. 
  • Methodological Investigation of Cochrane Reviews of Complex Interventions (MICCI): This research has been published. Link
  • Extending the Cochrane ‘Risk of bias’ tool to assess risk of bias in randomized trials with non-parallel-group designs, and non-randomized studies: The Group have developed the version of the tool for non-randomized studies (NRS) with defined bias domains and strategies for their assessment (signalling questions). They are also completing work on a similar tool for nonstandard designs. 
  • Addressing missing trial participant data in Cochrane Reviews: 
  • Methods for comparing multiple interventions in Intervention reviews and Overviews of reviews: A one-day workshop at the Vienna Colloquium disseminated guidance developed in the project. The workshop introduced the concepts and methods of indirect comparison and network meta-analysis in the context of a Cochrane review. Convenors of the CMIMG have drafted the new Handbook Chapter on Comparing Multiple Interventions targeting both authors and editors. 

For more detail on these projects see Cochrane Methods Suppplements 2015 and 2016