Prognosis Exemplars

Prognosis Exemplar Review Initiative
A small number of exemplar reviews have been approved by Cochrane and will be published in the Cochrane Library as they are completed. Each of these reviews addresses an important type of prognosis research (i.e. prognostic factors, prognostic models, and overall prognosis) and the methodological development and refinement for these reviews will be used to inform and assist authors of future systematic reviews of prognostic studies.

Prognostic Factor Exemplars:
1.   Individual recovery expectations and prognosis of outcomes in non-specific low back pain (Protocol) (Hayden et al., Cochrane Back and Neck)
2.   Prognostic factors in Crohn's disease: an exemplar systematic review (Feagan et al., Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders)
3.   Laboratory testing and clinical implications of anti-HLA antibodies for kidney transplantation (Keown et al., Cochrane Kidney and Transplant)
4.   Interim PET for prognosis in adults with Hodgkin lymphoma: a prognostic factor exemplar review (Protocol) (Skoetz et al., Cochrane Haematological Malignancies)

Prognostic Model Exemplars:
5.   Prediction models for the risk of postoperative nausea and vomiting (Protocol) (Pace et al., Cochrane Anaesthesia)
6.   Prognostic models for chronic lymphocytic leukaemia: an exemplar systematic review and meta-analysis (Protocol) (Skoetz et al., Cochrane Haematological Malignancies)

Overall Prognosis Exemplars:
7.   Prevalence of autism spectrum disorder after one or more years in children diagnosed with autism spectrum disorder (Brignell et al., Cochrane Developmental, Psychosocial and Learning Problems)
8.   Course and prognosis of medically unexplained symptoms (Cochrane Common Mental Disorders)
9.   Neurodevelopmental outcome and follow-up for cardiopulmonary failure supported by extracorporeal life support (ECLS) in children (birth to 16 years) (Aparna et al., Cochrane Developmental, Psychosocial & Learning Problems)
10. Prognosis of patients with interstitial lung disease without treatment or with ineffective therapies (Goh et al., Cochrane Airways)

Two key contributions supported by Cochrane, led by the convenors of the Prognosis Methods Group (PMG), are the Exemplar programme and funding to develop both prognosis methods and capacity for implementation. The development of approved and published exemplars, with annotation and related tools, are important steps to develop the standards and to build capacity for these review types. The PMG convenors, along with the authors of these exemplar reviews are working to develop quality resources for future prognostic review authors. Until the development of the exemplars and the associated resources are complete the registration of prognostic review titles will be restricted.

Please contact either Jackie Chandler (Methods Coordinator) or Toby Lasserson (Senior Editor) if your Group wishes to register a title of a prognostic question.