The Cochrane Handbook for Systematic Reviews of Interventions includes guidance on incorporating adverse effects in systematic reviews.  A discussion paper on the methods used has also been published in BMC Medical Research Methodology.

Loke  YK, Price D, Herxheimer A. Systematic reviews of adverse effects: framework for a structured approach    BMC Med Res Methodol 2007;7:32.

Cochrane hosts a dedicated Cochrane Training website, containing online training modules on different aspects of conducting a Cochrane systematic review.

Cochrane also hosts Cochrane Learning Live which contains webinars on adverse effects such as Adverse effects 1: How to overcome the challenge of reviewing adverse effects and Adverse effects 2: Searching for adverse effects

To adjust for outcome reporting bias in trials see the ORBIT methods platform for researchers that can easily be applied by non-methodologists

For further information and advice please join our discussion list at or contact a member of our specialist advisory panel.