Ongoing reviews

Ongoing reviews of prognosis studies

Cochrane invites prospective authors to propose new Cochrane Reviews by submitting a proposal in Editorial Manager. Please see the Cochrane library information for authors for further details.

CRG considering to register a title of a prognostic question can contact Anneke Damen (Coordinator) CochranePMG@umcutrecht.nl for support and to request methodological peer review.


Overall Prognosis reviews:

  1. Overall prognosis of preschool autism spectrum disorder diagnoses (Full review) (Brignell et al. 2022)
  2. Prognosis of adults and children following a first unprovoked seizure (Full review) (Neligan et al. 2023)
  3. Prognosis of adults with idiopathic pulmonary fibrosis without treatment or without effective therapies (Protocol) (Khor et al. 2017)
  4. Persistence of immunoglobulin G after natural infection with SARS‐CoV‐2 (Protocol) (Kreuzberger et al. 2021)
  5. Real-world prognosis of eyes with diabetic macular oedema receiving treatment with vascular endothelial growth factor (VEGF) inhibitors (Protocol) (Bhandari et al. 2021)
  6. Long-term prognosis of low language proficiency in children (Protocol) (Hagen et al. 2023)
  7. Overall prognosis of acute and chronic musculoskeletal, widespread, and neuropathic pain in children and adolescents (Protocol) (Montgomery et al. 2023)
  8. Overall prognosis of index lung cancer recurrence or of second primary lung cancer in people with non-small cell lung cancer operated with complete resection (Protocol) (Laforge et al. 2024)


Prognostic Factor reviews:

  1. Protease activity as a prognostic factor for wound healing in venous leg ulcers (Full review) (Westby et al. 2018)
  2. Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia (Full review) (Richter et al. 2018)
  3. Individual recovery expectations and prognosis of outcomes in non-specific low back pain (Full review) (Hayden et al. 2019)
  4. Interim PET for prognosis in adults with Hodgkin lymphoma: a prognostic factor exemplar review (Full review) (Aldin et al. 2020)
  5. Mammographic density, endocrine therapy, and breast cancer risk: a prognostic and predictive biomarker review (Full review) (Atakpa et al. 2021)
  6. Prognostic value of test(s) for O6-methylguanine-DNA methyltransferase (MGMT) promotermethylation for predicting overall survival in people with glioblastoma treated with temozolomide (Full review) (McAleenan et al. 2021)
  7. Anticholinergic burden for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome (Full review) (Taylor-Rowan et al. 2021)
  8. Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia (Full review) (Taylor-Rowan et al. 2022)
  9. Impact of residual disease as a prognostic factor for survival in women with advanced epithelial ovarian cancer after primary surgery (Full review) (Bryant et al. 2022)
  10. Obesity as an independent risk factor for COVID-19 severity and mortality (Full review) (Najafabadi et al. 2023, rapid review)
  11. Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy (Full review) (Perais et al, 2023)
  12. Sex and gender for predicting patient relevant outcomes in kidney transplantation (Full review) (Jayanti et al. 2024)
  13. Diabetes as a risk factor for tuberculosis disease (Full review) (Franco et al. 2024)
  14. Undernutrition as a risk factor for tuberculosis disease (Full review) (Franco et al. 2024)
  15. Prognostic value of the androgen receptor in addition to the established hormone receptors and HER2 status for predicting survival in women with early breast cancer (Protocol) (Lokuhetty et al. 2020)
  16. Sex as a prognostic factor in people with symptomatic acute pulmonary embolism (Protocol) (Lopez-Alcade et al. 2021)
  17. Prognostic factors predicting an unprovoked seizure recurrence in children and adults following a first unprovoked seizure (Protocol) (Adan et al. 2021)
  18. Gut microbial biomarkers for predicting adverse outcomes in people with chronic kidney disease (Protocol) (Cooper et al. 2022)
  19. Prognostic factors for return to work in breast cancer survivors (Protocol) (Tamminga et al. 2022)
  20. Predictive factors for BK polyomavirus infection in solid organ transplant recipients (Protocol) (Gately et al. 2022)
  21. Heart failure symptoms as predictors of hospital admission, readmission and all-cause mortality (Protocol) (Rizwan Ali et al. 2022)
  22. Prognostic factors for predicting progression of open angle glaucoma in adults (Protocol) (Prabhath Piyasena et al. 2022)
  23. Prediction of disease specific and overall survival in men with prostate cancer using the Decipher assay (Protocol) (Garegnani et al. 2023)
  24. Prognostic accuracy of imaging findings for predicting morbidity and mortality in patients with COVID-19 (Protocol) (Islam et al. 2023)
  25. Factors for predicting treatment success and severe adverse events of chimeric antigen receptor (CAR) T-cell therapy i relapsed or refractory diffuse large B-cell lymphoma (Protocol) (Hirsch et al. 2023)
  26. Prognostic factors for return to work following knee arthroplasty (Protocol) (Strijbos et al. 2024)
  27. Predictive value of homologous recombination deficiency status for survival outcomes in primary tubo-ovarian high-grade serous carcinoma (Protocol) (Zwimpfer et al. 2024)
  28. Molecular biomarkers for predicting complete response to preoperative chemoradiation in people with locally advanced rectal cancer (Protocol) (De Lacavalerie et al. 2024)
  29. Prognostic value of blood eosinophils for predicting survival and treatment outcomes in people with non-small cell lung cancer (Protocol) (Sultana et al. 2025)


Prognostic Model reviews:

  1. Prognostic models for chronic lymphocytic leukaemia: an exemplar systematic review and meta-analysis (Full review) (Kreuzberger et al. 2020)
  2. The added value of different biomarkers to the Revised Cardiac Risk Index to predict major adverse cardiac events and mortality after noncardiac surgery (Full review) (Vernooij et al. 2021)
  3. Prognostic models for predicting relapse or recurrence in depression (Full review) (Moriarty et al. 2021)
  4. Prognostic models for predicting clinical disease progression, worsening and activity in people with multiple sclerosis (Full review) (Reeve et al. 2023)
  5. Multi-domain prognostic models used in middle-aged adults without known cognitive impairment for predicting subsequent dementia (Full review) (Geethadevi et al. 2023)
  6. Prediction models for the risk of postoperative nausea and vomiting (Protocol) (Pace et al. 2014)
  7. Prognostic models for predicting the severity and mortality in people with acute pancreatitis (Protocol) (Gurusamy et al. 2018)
  8. Risk prediction models for familial breast cancer (Protocol) (McGarrigle et al. 2018)
  9. Model for end stage liver disease for prediction of mortality in people with cirrhosis (Protocol) (D’Amico et al. 2021)
  10. Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients (Protocol) (Takada et al. 2021)
  11. Prognostic models for predicting recurrence in women with endometrial cancer (Protocol) (Wan et al. 2021)
  12. Prognostic models for colorectal cancer incidence and mortality in patients with inflammatory bowel disease (Protocol) (Gantzel et al. 2023)