Ongoing reviews

Ongoing reviews of prognosis studies

A small number of prognosis reviews have been approved by Cochrane and will be published in the Cochrane Library as they are completed. Each of these reviews addresses an important type of prognosis research (i.e. prognostic factors, prognostic models, and overall prognosis) and the methodological development and refinement for these reviews will be used to inform and assist authors of future systematic reviews of prognostic studies.
Please contact Kayleigh Kew (Senior Methods Editor) kkew@cochrane.org if your Group wishes to register a title of a prognostic question.


Overall Prognosis reviews:

  1. Overall prognosis of preschool autism spectrum disorder diagnoses (Protocol) (Brignell et al., Cochrane Developmental, Psychosocial and Learning Problems)
  2. Prognosis of adults and children following a first unprovoked seizure (Protocol) (Neligan et al., Cochrane Epilepsy)
  3. Neurodevelopmental outcome and follow-up for cardiopulmonary failure supported by extracorporeal life support (ECLS) in children (birth to 16 years) (Hoskote et al., Cochrane Developmental, Psychosocial & Learning Problems)
  4. Incidence and outcomes of COVID-19 in people with chronic kidney disease (Strippoli et al., Cochrane Kidney and Transplant)
  5. Persistence of humoral immune response in people infected with SARS-CoV-2 (Skoetz et al., Cochrane Haematology)


Prognostic Factor reviews:

  1. Protease activity as a prognostic factor for wound healing in venous leg ulcers (Full review) (Westby et al. 2018, Cochrane Wounds)
  2. Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia (Full review) (Richter et al. 2018, Cochrane Metabolic and Endocrine Disorders)
  3. Individual recovery expectations and prognosis of outcomes in non-specific low back pain (Full review) (Hayden et al., Cochrane Back and Neck)
  4. Interim PET for prognosis in adults with Hodgkin lymphoma: a prognostic factor exemplar review (Full review) (Skoetz et al., Cochrane Haematological Malignancies)
  5. Mammographic density, endocrine therapy, and breast cancer risk: a prognostic and predictive biomarker review (Protocol) (Atakpa et al., Cochrane Breast Cancer)
  6. Prognostic value of test(s) for O6-methylguanine-DNA methyltransferase (MGMT) promotermethylation for predicting overall survival in people with glioblastoma treated with temozolomide (Protocol) (McAleenan et al., Cochrane Neuro-oncology)
  7. Anticholinergic burden for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome (Protocol) (Quinn et al., Cochrane Dementia and Cognitive Improvement)
  8. Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy (Protocol) (Perais et al., Cochrane Eyes and Vision)
  9. Prognostic value of the androgen receptor in addition to the established hormone receptors and HER2 status for predicting survival in women with early breast cancer (Protocol) (Lokuhetty et al., Cochrane Breast Cancer)
  10. Sex as a prognostic factor in people with symptomatic acute pulmonary embolism (Protocol) (Lopez-Alcade et al., Cochrane Vascular)
  11. Prognostic factors predicting an unprovoked seizure recurrence in children and adults following a first unprovoked seizure (Protocol) (Adan et al., Cochrane Epilepsy)
  12. Prognostic factors in Crohn's disease: an exemplar systematic review (Feagan et al., Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders)
  13. Prognostic factors for recovery and non-recovery in patients with non-specific neck pain (Domingues et al., Cochrane Musculoskeletal)
  14. Molecular biomarkers for predicting response to preoperative chemo-radiation in patients with locally advanced rectal cancer (De Lacavalerie et al., Cochrane Colorectal Cancer)
  15. The prognostic value of the Decipher gene essay in patients with prostate cancer (Vernooij et al., Cochrane Urology)
  16. Gut microbial biomarkers for predicting adverse outcomes in people with chronic kidney disease (Cooper et al., Cochrane Kidney and Transplant)
  17. Prediction of micro and macrovascular complications in patients with diabetes mellitus and chronic kidney disease using HbA1c, self-glucose monitoring, and alternative biomarkers (Tunnicliffe et al., Cochrane Kidney and Transplant)
  18. Overall prognosis of and prognostic factors for musculoskeletal pain in children and adolescents (Montgomery et al., Cochrane Pain Palliative and Supportive Care )
  19. Obesity as an independent risk factor for COVID-19 severity and mortality (Chan et al., rapid review)
  20. Real-world prognosis of eyes with diabetic macular edema receiving treatment with vascular endothelial growth factor inhibitors (Bhandari et al., Cochrane Eyes and Vision)
  21. Effect of duration of macular detachment on final visual acuity after successful repair of macula-off retinal detachment (Yorston et al., Cochrane Eyes and Vision)
  22. Sex and gender for predicting patient relevant outcomes in kidney transplantation (Javanti et al., Cochrane Kidney and Transplant)


Prognostic Model reviews:

  1. Prognostic models for chronic lymphocytic leukaemia: an exemplar systematic review and meta-analysis (Full review) (Kreuzberger et al., Cochrane Haematological Malignancies)
  2. Prediction models for the risk of postoperative nausea and vomiting (Protocol) (Pace et al., Cochrane Anaesthesia)
  3. Prognostic models for predicting the severity and mortality in people with acute pancreatitis (Protocol) (Gurusamy et al., Cochrane Upper Gastrointestinal and Pancreatic Diseases Group)
  4. The added value of different biomarkers to the Revised Cardiac Risk Index to predict major adverse cardiac events and mortality after noncardiac surgery (Protocol) (Vernooij et al., Cochrane Heart)
  5. Risk prediction models for familial breast cancer (Protocol) (McGarrigle et al., Cochrane Breast Cancer)
  6. Prognostic models for predicting relapse or recurrence in depression (Protocol) (Moriarty et al., Cochrane Common Mental Disorders)
  7. Prognostic models for predicting clinical disease progression, worsening and activity in people with multiple sclerosis (Protocol) (Irmak On Seker et al., Cochrane Multiple Sclerosis and Rare Diseases)
  8. Model for end stage liver disease for prediction of mortality in people with cirrhosis (Protocol) (D’Amico et al., Cochrane Hepato-Biliary)
  9. Prognostic models for predicting recurrence in women with endometrial cancer (Wan et al., Cochrane Gynaecological, Neuro-oncology and Orphan Cancers)
  10. Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients (Takada et al., Cochrane Haematology )
  11. Prognostic models for predicting functional decline in older Emergency Department patients (Kabell Nissen et al., Cochrane Emergency and Cricital Care)
  12. Multi-domain prognostic models, used in middle aged adults without known cognitive impairment, for predicting subsequent dementia (Cross et al., Cochrane Dementia)