Ongoing reviews

Ongoing reviews of prognosis studies
A small number of exemplar reviews have been approved by Cochrane and will be published in the Cochrane Library as they are completed. Each of these reviews addresses an important type of prognosis research (i.e. prognostic factors, prognostic models, and overall prognosis) and the methodological development and refinement for these reviews will be used to inform and assist authors of future systematic reviews of prognostic studies.

Overall Prognosis reviews:
1.   Overall prognosis of preschool autism spectrum disorder diagnoses (Protocol) (Brignell et al., Cochrane Developmental, Psychosocial and Learning Problems)
2.   Prognosis of adults with idiopathic pulmonary fibrosis without treatment or without effective therapies (Protocol) (Khor et al., Cochrane Airways )
3.   Neurodevelopmental outcome and follow-up for cardiopulmonary failure supported by extracorporeal life support (ECLS) in children (birth to 16 years) (Hoskote et al., Cochrane Developmental, Psychosocial & Learning Problems)

Prognostic Factor reviews:
1.   Protease activity as a prognostic factor for wound healing in venous leg ulcers (Full review) (Westby et al. 2018, Cochrane Wounds)
2.   Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia (Full review) (Richter et al. 2018, Cochrane Metabolic and Endocrine Disorders)
3.   Individual recovery expectations and prognosis of outcomes in non-specific low back pain (Protocol) (Hayden et al., Cochrane Back and Neck)
4.   Interim PET for prognosis in adults with Hodgkin lymphoma: a prognostic factor exemplar review (Protocol) (Skoetz et al., Cochrane Haematological Malignancies)
5.   Mammographic density, endocrine therapy, and breast cancer risk: a prognostic and predictive biomarker review (Protocol) (Atakpa et al., Cochrane Breast Cancer)
6.   Prognostic value of test(s) for O6-methylguanine-DNA methyltransferase (MGMT) promotermethylation for predicting overall survival in people with glioblastoma treated with temozolomide (Protocol) (McAleenan et al., Cochrane Neuro-oncology)
7.   Prognostic factors in Crohn's disease: an exemplar systematic review (Feagan et al., Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders)
8.   Sex as a prognostic factor in people with symptomatic acute pulmonary embolism (Lopez-Alcade et al., Cochrane Vascular)
9.   Anticholinergic burden for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome (Quinn et al., Cochrane Dementia and Cognitive Improvement)
10.   Prognosis following a first unprovoked seizure and prognostic factors predicting seizure recurrence and epilepsy diagnosis (Neligan et al., Cochrane Epilepsy)
11.   Prognostic factors for recovery and non-recovery in patients with non-specific neck pain (Hayden et al., Cochrane Musculoskeletal)

Prognostic Model reviews:
1.   Prediction models for the risk of postoperative nausea and vomiting (Protocol) (Pace et al., Cochrane Anaesthesia)
2.   Prognostic models for chronic lymphocytic leukaemia: an exemplar systematic review and meta-analysis (Protocol) (Skoetz et al., Cochrane Haematological Malignancies)
3.   Prognostic models for predicting the severity and mortality in people with acute pancreatitis (Protocol) (Gurusamy et al., Cochrane Upper Gastrointestinal and Pancreatic Diseases Group)
4.   The added value of different biomarkers to the Revised Cardiac Risk Index to predict major adverse cardiac events and mortality after noncardiac surgery (Protocol) (Vernooij et al., Cochrane Heart)
5.   Risk prediction models for familial breast cancer (Protocol) (McGarrigle et al., Cochrane Breast Cancer)
6.   Prognostic models for predicting relapse or recurrence in depression (Moriarty et al., Cochrane Common Mental Disorders)


Please contact Toby Lasserson (Senior Editor) tlasserson@cochrane.org if your Group wishes to register a title of a prognostic question.