Guidance on use of IPD

Useful reading material relevant to undertaking IPD meta-analyses
Chapter 19: Reviews of individual patient data. In: Higgins JPT, Green S (editors), Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Stewart LA, Tierney JF, Clarke M. (Available from
Meta-analysis of individual participant data: rationale, conduct, and reporting. Riley RD et al. BMJ 2010. (PMID: 20139215)
Individual patient data meta-analyses Clarke MJ. Best Pract Res Clin Obstet Gynaecol 2005. (PMID: 15749065)
To IPD or not to IPD? Advantages and disadvantages of systematic reviews using individual patient data. Stewart, LA et al. Eval Health Prof 2002. (PMID: 11868447)
Individual patient data meta-analysis of randomised anti-epileptic drug
monotherapy trials. Williamson PR, Marson AG, Tudur C, Hutton JL and Chadwick D. Journal of Evaluation in Clinical Practice 2000. (PMID: 10970014)
Chapter 6: Obtaining individual patient data from randomised controlled trials. Clarke MJ, Stewart LA. In: Matthias Egger, George Davey Smith, Douglas Altman (editors), Systematic Reviews in Health Care: Meta-analysis in Context. BMJ Books, London 2001. (Link to website)

Individual patient data meta-analyses in cancer. Clarke, M et al. Brit J Cancer 1998. (PMID: 9667689)
Meta-analyses using individual patient data. Clarke MJ, Stewart LA. J Eval Clin Pract 1997. (PMID: 9406108)
Practical methodology of meta-analyses (overviews) using updated individual patient data. Cochrane Working Group. Stewart LA et al. Stats Med 1995. (PMID: 8552887)
Systematic reviews of randomized controlled trials: the need for complete data. Clarke MJ, Stewart LA. J Eval Clin Pract 1995. (PMID: 9238566)
Obtaining data from randomised controlled trials: how much do we need for reliable and informative meta-analyses? Clarke MJ, Stewart LA.  BMJ 1994. (PMID: 7950694)