It’s hard to stay up-to-date with the latest health evidence. Listen to leading experts and Cochrane review authors explain in plain language the evidence and findings of their high-impact reviews. In 5 minutes or less, healthcare professionals to patients and families can understand the latest trusted evidence to help make better informed decisions.

For 20 years, Cochrane has produced systematic reviews which are internationally recognized as the highest standard in evidence-based health care resources. Cochrane works collaboratively with contributors around the world to produce authoritative, relevant, and reliable evidence.

You can view and search our entire catalogue of hundreds of podcasts or subscribe via Apple Podcast, Google Podcasts, or Spotify for the latest updates.

Monday, March 7, 2022

Clinical Trials Day is celebrated on 20 May marking the day in 1747 on which James Lind is believed to have begun the first known controlled trial, comparing different treatments for scurvy which was common among sailors in the British Royal Navy. Watch a video explaining the trial to see history in the making.

Learn about Cochrane systematic reviews and how clinical trials are used:

Advocacy on clinical trial transparency

Registering and reporting the results of clinical trials is an ethical, and often legal, responsibility. However, it is well documented that the results of many studies are never published. This contributes to research waste and can even lead to people being harmed.  Cochrane’s community is active in campaigning for improved clinical trial transparency.

During the last 12 months, there have been major milestones in this area. At last year’s World Health Assembly, WHO Member States adopted a resolution on clinical trials which references transparency obligations. As well as demonstrating high-level political support for the importance of robust, transparent clinical trial practices, the resolution has spearheaded a number of activities as part of its implementation.

In addition, the UK Government recently announced new stricter legislation formalising the requirements to register and report on clinical trials in a timely manner. This is in line with our long-term advocacy recommendations.

However, there is still much more to be done in this area.

Cochrane’s systematic reviews rely upon the results of clinical trials. To assess the effectiveness and safety of healthcare interventions, we need to know what trials were done, how they were conducted and what their findings were. Without access to detailed information from all clinical trials, we cannot have a full picture of the evidence.

"While it is heartening to have seen some significant improvements in clinical trial transparency in recent years, there is still much more to be done worldwide," says Emma Thompson, Cochrane Advocacy and Partnership Lead."Cochrane will continue to push for the fulfilment of this key ethical, and often legal, responsibility."

Cochrane's clinical trial transparency advocacy: 

• Cochrane and Cochrane Germany participate in live session on driving clinical trial reporting
• Cochrane encourages participation in WHO consultations following resolution
• Article by Cochrane France on clinical trial transparency and COVID-19 trials
• Cochrane Convenes report, which covers key issues around clinical trials in emergency conditions
• Cochrane participates in a session on Clinical Trials and COVID-19
• Cochrane Sweden host webinar on clinical trial transparency
• Cochrane Germany article on clinical trial transparency in the EU and advocacy activities in Germany
• Cochrane's statement to the 74th World Health Assembly
• Cochrane shows support for WHO-ICMRA statement on transparency and data integrity
• Cochrane signs letter asking medicines regulators in Europe to address unpublished clinical trials
• US FDA begins enforcement of clinical trial transparency regulation
• Cochrane Belgium partners on clinical trial transparency report
• Cochrane Austria launches joint trial transparency report
• Cochrane Sweden highlights under-reporting of Swedish clinical trials
• Read the Evidently Cochrane blog post 'Retention to clinical trials: how can we keep participants involved?'
• Read the Cochrane Review 'Strategies to improve retention in randomised trials'
  
• Clinical Trial Transparency: A guide for policymakers - English, German, Italian

Cochrane Library systematic reviews of interest: 

• Strategies to improve retention in randomised trials
• Factors that impact on recruitment to randomised trials in health care: a qualitative evidence synthesis

 

Friday, May 19, 2023