List of prospective meta-analysis studies

The PMA Methods Group has compiled a list of known PMA studies and protocols. If you know of any more, please email the details to

Note: the PMA Methods Group has completed a PMA scoping review, which we plan to publish. This page will be updated following publication.

Completed PMAs that have reported results

Askie LM, Espinoza D, Martin A, Daniels LA, Mihrshahi S, Taylor R, Wen LM, Campbell K, Hesketh KD, Rissel C, Taylor B, Magarey A, Seidler AL, Hunter KE, Baur LA. Interventions commenced by early infancy to prevent childhood obesity - the EPOCH Collaboration: an individual participant data prospective meta-analysis of four randomised controlled trials. Pediatric Obesity. 2020:e12618. [Pubmed]

Askie L, Darlow BA, Finer N, Schmidt B, Stenson B, Tarnow-Mordi W, David PG, Carlo WA, Brocklehurst P, Davies LC, Das A, Rich W, Gantz MG, Roberts RS, Whyte RK, Costantini L, Poets C, Asztalos E, Battin M, Halliday HL, Marlow N, Tin W, King A, Juszczak E, Morley CJ, Doyle LW, Gebski V, Hunter KE, Simes RJ, for the Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration. Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 2018;319(21):2190-201. [Pubmed]

Chen ZM, Sandercock P, Pan HC, Counsell C, Collins R, Liu LS, Xie JX, Warlow C, Peto R. Indications for early aspirin use in acute ischemic stroke: A combined analysis of 40 000 randomized patients from the Chinese acute stroke trial and the international stroke trial. On behalf of the CAST and IST collaborative groups. Stroke 2000; 31:1240-1249. [PubMed]

Cornu C, Boutitie F, Candelise L, Boissel JP, Donnan GA, Hommel M, Jaillard A, Lees KR. Streptokinase in acute ischemic stroke: an individual patient data meta-analysis: The Thrombolysis in Acute Stroke Pooling Project. Stroke 2000; 31:1555-1560. [PubMed]

[No authors listed]. Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet 1995; 345:939-944. [PubMed]

Margitic SE, Morgan TM, Sager MA, Furberg CD. Lessons learned from a prospective meta-analysis. J Am Ger Soc 1995; 43(4):435-439. [PubMed]

Marty, ME, Coombes RC, Peckitt C, Pérez López FR, Tres A, Morvan F, Tubiana-Mathieu N, Espié M and Bliss JM, on behalf of the International Collaborative Cancer Group (ICCG). Prospective meta-analysis of randomised trials of cyclophosphamide, methotrexate & fluorouracil (CMF) vs fluorouracil, epirubicin & cyclophosphamide (FEC) chemotherapy in early breast cancer. J Clin Onc 2004; 22(14S July 15 Supplement):592.

Miller JP, Schechtman KB, Province MA, Arfken CL, Smlth DS, Mulrow CD, Ory MG, Welso SM, Hadley EC and FICStT Study Group. Preplanned meta-analyses in a clinical trial aimed at reducing frailty and injuries in older persons. Controlled Clinical Trials 1991; 12:630-631. [ScienceDirect]

Nitti D, Wils J, Dos Santos JG, Fountzilas G, Conte PF, Sava C, Tres A, Coombes RC, Crivellari D, Marchet A, Sanchez E, Bliss JM, Homewood J, Couvreur ML, Hall E, Baron B, Woods E, Emson M, Van Cutsem E, Lise M; EORTC GI Group; ICCG. Randomized phase III trials of adjuvant FAMTX or FEMTX compared with surgery alone in resected gastric cancer. Ann Onc 2006; 17:262-269. [PubMed]

The PPP Project Investigators. Design, rational, and baseline characteristics of the Prospective Pravastatin Pooling (PPP) project--a combined analysis of three large-scale randomized trials: Long-term Intervention with Pravastatin in Ischemic Disease (LIPID), Cholesterol and Recurrent Events (CARE), and West of Scotland Coronary Prevention Study (WOSCOPS). Am J Cardiol 1995 76:899-905. [PubMed]

Walker MD. Atrial fibrillation and antithrombotic prophylaxis: a prospective meta-analysis. Lancet 1989; 362:325-326. [PubMed]

Writer WD, Stienstra R, Eddleston JM, Gatt SP, Griffin R, Gutsche BB, Joyce TH, Hedlund C, Heeroma K, Selander D. Neonatal outcome and mode of delivery after epidural analgesia for labour with ropivacaine and bupivacaine: a prospective meta-analysis. Br J Anaest 1998; 81:713-717. [PubMed]


Published PMA Protocols

Levett K, Lord S, Dahlen H, Smith C, Girosi F, Downe S, Finlayson K, Fleet J, Steen M, Davey M, Newnham E, Werner A, Arnott L, Sutcliffe K, Seidler AL, Hunter K, Askie L. The AEDUCATE Collaboration. Comprehensive antenatal education birth preparation programmes to reduce the rates of caesarean section in nulliparous women. Protocol for an individual participant data prospective meta-analysis. BMJ Open 2020;10:e037175. [Pubmed]

Askie LM, Brocklehurst P, Darlow BA, Finer N, Schmidt B, Tarnow-Mordi W. NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol. BMC Pediatrics 2011; 11:6. [Pubmed]

Askie LM, Baur LA, Campbell K, Daniels L, Hesketh K, Magarey A, Mihrshahi S, Rissel C, Simes RJ, Taylor B, Taylor R, Voysey M, Wen LI, on behalf of the EPOCH Collaboration. The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis. BMC Public Health 2010; 10:728. [BMC]

[No authors listed]. Protocol for a prospective collaborative overview of all current and planned randomized trials of cholesterol treatment regimens. Am J Cardiol 1995; 75:1130-1134. [PubMed]

Protocol for prospective collaborative overviews of major randomized trials of blood-pressure-lowering treatments. J Hyper 1998; 16:127-137. [PubMed]

Turok D, Simonsen SE, Schulz KF. Misoprostol for cervical priming prior to IUD insertion in nulliparous women (Protocol). Cochrane Db Syst Rev 2010, Issue 1. Art. No.: CD008278. [Cochrane Library]