Published DTA reviews

Our Reviews

Full list:

By subtopic:

Diagnostic test accuracy (210)
C-PIB-PET for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI)
18F PET with florbetaben for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)
18F PET with flutemetamol for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)
18F PET with florbetapir for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI)
Duplex ultrasound for diagnosing symptomatic carotid stenosis in the extracranial segments (protocol stage)
Mini-Cog for the diagnosis of Alzheimer's disease dementia and other dementias within a community setting
Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within community dwelling populations
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within a general practice (primary care) setting
Abdominal ultrasound and alpha-foetoprotein for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease
Abdominal ultrasound for diagnosing abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals
Imaging modalities for characterising focal pancreatic lesions
Non-invasive diagnostic tests for infection
Accuracy of MRI, ultrasound and vaginal assessment for the diagnosis of levator ani muscle avulsion in women (protocol stage)
Prehospital stroke scales as screening tools for early identification of stroke and transient ischemic attack
Amplitude-integrated electroencephalography compared with conventional video-electroencephalography for detection of neonatal seizures (protocol stage)
Amylase in drain fluid for the diagnosis of pancreatic leak in post-pancreatic resection
Ankle brachial index for the diagnosis of lower limb peripheral arterial disease
Antenatal screening for Down's syndrome: generic protocol (protocol stage)
Anti-GM1 antibody testing for multifocal motor neuropathy (protocol stage)
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within a secondary care setting
Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI)
Airway physical examination tests for detection of difficult airway management in apparently normal adult patients
Biomarkers for assessing disease activity in inflammatory bowel disease (protocol stage)
Biomarkers for diagnosis of acute appendicitis in adults (protocol stage)
Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis
Blood biomarkers for the non-invasive diagnosis of endometriosis
Serum C-reactive protein, procalcitonin, and lactate dehydrogenase for the diagnosis of pancreatic necrosis
Biochemical tests of placental function versus ultrasound assessment of fetal size for stillbirth and small-for-gestational-age infants
Voxel-based morphometry for separation of schizophrenia from other types of psychosis in first episode psychosis
Brain natriuretic peptide and N-terminal brain natriuretic peptide for the diagnosis of hemodynamically significant patent ductus arteriosus in preterm neonates (protocol stage)
Brief alcohol questionnaires for identifying hazardous, harmful and dependent alcohol use in primary care (protocol stage)
C-reactive protein for diagnosing late-onset infection in newborn infants
Calcitonin testing for detection of medullary thyroid cancer in people with thyroid nodules
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19
Sentinel node biopsy for diagnosis of lymph node involvement in endometrial cancer
Sentinel node assessment for diagnosis of groin lymph node involvement in vulval cancer
Canadian C-spine rule and the National Emergency X-Radiography Utilization Study (NEXUS) for detecting clinically important cervical spine injury following blunt trauma (protocol stage)
Capsule endoscopy for the diagnosis of oesophageal varices in people with chronic liver disease or portal vein thrombosis
Carbon dioxide detection for diagnosis of inadvertent respiratory tract placement of enterogastric tubes in children (protocol stage)
Carbon dioxide detection for testing nasogastric tube placement in adults (protocol stage)
Cardiac testing for coronary artery disease in potential kidney transplant recipients
Clinical judgement by primary care physicians for the diagnosis of all-cause dementia or cognitive impairment in symptomatic people (protocol stage)
Clinical symptoms and signs for the diagnosis of Mycoplasma pneumoniae in children and adolescents with community-acquired pneumonia
Clinical symptoms, signs and tests for identification of impending and current water-loss dehydration in older people
Triage tools for detecting cervical spine injury in pediatric trauma patients
Combination of the non-invasive tests for the diagnosis of endometriosis
Combination of magnetic resonance cholangiopancreatography and conventional magnetic resonance imaging for the diagnosis of bile duct stenosis (protocol stage)
Computed tomography versus magnetic resonance imaging versus bone scintigraphy for clinically suspected scaphoid fractures in patients with negative plain radiographs
Computed tomography angiography or magnetic resonance angiography for detection of intracranial vascular malformations in patients with intracerebral haemorrhage
Computed tomography for the diagnosis of hepatocellular carcinoma in chronic advanced liver disease (protocol stage)
Confusion Assessment Method for the intensive care unit (CAM-ICU) for the diagnosis of delirium in adults in critical care settings (protocol stage)
Continuous glucose monitoring systems for the diagnosis of cystic fibrosis-related diabetes (protocol stage)
Contrast-enhanced ultrasound compared with computed tomography, magnetic resonance imaging, and positron emission tomography-computed tomography for diagnosing liver metastases in people with newly diagnosed colorectal cancer (protocol stage)
Contrast-enhanced ultrasound for the diagnosis of hepatocellular carcinoma in advanced chronic liver disease (protocol stage)
D-dimer test for excluding the diagnosis of pulmonary embolism
D-Dimer tests for the diagnosis of deep venous thrombosis in symptomatic hospital outpatients with a clinical prediction rule (protocol stage)
Day 5 versus day 3 embryo biopsy for preimplantation genetic testing for monogenic/single gene defects (protocol stage)
Depression rating scales for detection of major depression in people with dementia (protocol stage)
Blood CEA levels for detecting recurrent colorectal cancer
Diagnosis of SARS-CoV-2 infection and COVID-19: accuracy of signs and symptoms; molecular, antigen, and antibody tests; and routine laboratory markers (protocol stage)
Diagnostic accuracy of different imaging modalities following computed tomography (CT) scanning for assessing the resectability with curative intent in pancreatic and periampullary cancer
Total serum bile acids or serum bile acid profile, or both, for the diagnosis of intrahepatic cholestasis of pregnancy
Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma (protocol stage)
Magnetic resonance imaging, magnetic resonance arthrography and ultrasonography for assessing rotator cuff tears in people with shoulder pain for whom surgery is being considered
Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults
Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis
Dopamine transporter imaging for the diagnosis of dementia with Lewy bodies
Doppler trans-thoracic echocardiography for detection of pulmonary hypertension in adults (protocol stage)
Duplex ultrasound for the detection of stenosis after peripheral arterial bypass grafting using autologous vein (protocol stage)
Duplex ultrasound for the diagnosis of symptomatic deep vein thrombosis in the lower limb (protocol stage)
Endometrial biomarkers for the non-invasive diagnosis of endometriosis
Endoscopic retrograde cholangiopancreatography versus intraoperative cholangiography for diagnosis of common bile duct stones
Endoscopic ultrasound versus magnetic resonance cholangiopancreatography for common bile duct stones
FibroTest, transient elastography method, and combined FibroTest and transient elastography method for diagnosis of severe hepatic fibrosis and cirrhosis in adults with chronic hepatitis C (protocol stage)
First rank symptoms for schizophrenia
Fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) computed tomography (CT) for the detection of bone, lung and lymph node metastases in rhabdomyosarcoma (protocol stage)
Forns index and 'FIB4' for staging of fibrosis in adults with chronic hepatitis C (protocol stage)
Guaiac-based faecal occult blood tests versus faecal immunochemical tests for colorectal cancer screening in average-risk individuals (protocol stage)
Diagnostic tests for autism spectrum disorder (ASD) in preschool children
Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection
Non-contact tests for identifying people at risk of primary angle closure glaucoma
Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma
Xpert MTB/RIF and Xpert Ultra assays for screening for pulmonary tuberculosis and rifampicin resistance in adults, irrespective of signs or symptoms
Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults
Serum or plasma ferritin concentration as an index of iron deficiency and overload
Addenbrooke’s Cognitive Examination III (ACE-III) and mini-ACE for the detection of dementia and mild cognitive impairment
Positron emission tomography (PET) and magnetic resonance imaging (MRI) for assessing tumour resectability in advanced epithelial ovarian/fallopian tube/primary peritoneal cancer
Point-of-care ultrasonography for diagnosing thoracoabdominal injuries in patients with blunt trauma
Chest ultrasonography versus supine chest radiography for diagnosis of pneumothorax in trauma patients in the emergency department
Computed tomography for diagnosis of acute appendicitis in adults
Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults
Exfoliative cytology for diagnosing basal cell carcinoma and other skin cancers in adults
High-frequency ultrasound for diagnosing skin cancer in adults
Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with mild cognitive impairment
Plasma and cerebrospinal fluid ABeta42 for the differential diagnosis of Alzheimer's disease dementia in participants diagnosed with any dementia subtype in a specialist care setting
AD-8 for detection of dementia across a variety of healthcare settings
Mini-Cog for the diagnosis of Alzheimer’s disease dementia and other dementias within a secondary care setting
Mini-Cog for the diagnosis of Alzheimer’s disease dementia and other dementias within a primary care setting
Visual inspection for diagnosing cutaneous melanoma in adults
Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma
Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas
Cytology versus HPV testing for cervical cancer screening in the general population
Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions
Imaging modalities for the detection of posterior compartment disorders in women with obstructed defaecation syndrome (protocol stage)
Imaging modalities for the non-invasive diagnosis of endometriosis
Intraoperative frozen section analysis for the diagnosis of early stage ovarian cancer in suspicious pelvic masses
Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer
Three-dimensional saline infusion sonography compared to two-dimensional saline infusion sonography for the diagnosis of focal intracavitary lesions
Diagnostic test accuracy of jolt accentuation for headache in acute meningitis in the emergency setting
Biomarkers for diagnosis of Wilson's disease
Laparoscopy for diagnosing resectability of disease in women with advanced ovarian cancer
Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in people living with HIV
Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults
Low cost versus other screening tests to detect cervical cancer or precancer in developing countries (protocol stage)
Magnetic resonance imaging (MRI) for diagnosis of acute appendicitis (protocol stage)
Magnetic resonance imaging versus computed tomography for detection of acute vascular lesions in patients presenting with stroke symptoms
Magnetic resonance imaging, computer tomography scan, and oesophagography for the diagnosis of oesophageal varices in patients with chronic liver disease or portal vein thrombosis (protocol stage)
Galactomannan detection for invasive aspergillosis in immunocompromised patients
(1→3)-β-D-glucan testing for the detection of invasive fungal infections in immunocompromised or critically ill people
Measures of antiretroviral adherence for detecting viral non-suppression in people living with HIV (protocol stage)
Galactomannan detection in broncho-alveolar lavage fluid for invasive aspergillosis in immunocompromised patients
Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations
Molecular assays for the diagnosis of sepsis in neonates
Montreal Cognitive Assessment for the diagnosis of Alzheimer’s disease and other dementias
MRI versus CT versus 18F-FDG PET-CT for detecting lymph node metastases in patients with head and neck squamous cell carcinoma (protocol stage)
Neuropsychological tests for the diagnosis of Alzheimer’s disease dementia and other dementias: a generic protocol for cross-sectional and delayed-verification studies (protocol stage)
Non-invasive imaging to detect vertebral artery stenosis (protocol stage)
Non-invasive test of liver fibrosis for the diagnosis of oesophageal varices in patients with chronic liver disease or portal vein thrombosis (protocol stage)
Operational Criteria Checklist for Psychotic Illness and Affective Illness (OPCRIT+) for diagnosing schizophrenia in people with psychotic symptoms (protocol stage)
Optical coherence tomography angiography for monitoring the treatment of neovascular age-related macular degeneration (protocol stage)
Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy
Peripheral venous blood gas analysis versus arterial blood gas analysis for the diagnosis of respiratory failure and metabolic disturbance in adults (protocol stage)
PET-CT for assessing mediastinal lymph node involvement in patients with suspected resectable non-small cell lung cancer
Physical examination for lumbar radiculopathy due to disc herniation in patients with low-back pain
Physical tests for shoulder impingements and local lesions of bursa, tendon or labrum that may accompany impingement
Red flags to screen for malignancy in patients with low-back pain
Red flags to screen for vertebral fracture in patients presenting with low-back pain
Platelet count, spleen length, and platelet count-to-spleen length ratio for the diagnosis of oesophageal varices in people with chronic liver disease or portal vein thrombosis
Point of care rapid test for diagnosis of syphilis infection in men and nonpregnant women (protocol stage)
Point of care rapid test for diagnosis of syphilis infection in pregnant women (protocol stage)
Point-of-care tests detecting HIV nucleic acids for diagnosis of HIV infection in infants and children aged 18 months or less (protocol stage)
Point-of-care viral load tests to detect high HIV viral load levels in HIV-positive people on antiretroviral therapy (protocol stage)
Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children
Procalcitonin, C-reactive protein, and presepsin for the diagnosis of sepsis in adults and children (protocol stage)
Plasma and cerebrospinal fluid amyloid beta for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)
CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)
Pulse oximetry screening for critical congenital heart defects
Rapid diagnostic tests for diagnosing uncomplicated malaria in endemic countries
Rapid diagnostic tests for plague
Rapid tests for the diagnosis of visceral leishmaniasis in patients with suspected disease
Rapid diagnostic tests versus clinical diagnosis for managing people with fever in malaria endemic settings
Rapid diagnostic tests for malaria in endemic countries
Rapid diagnostic tests for diagnosing uncomplicated non-falciparum or malaria in endemic countries
Regional Cerebral Blood Flow Single Photon Emission Computed Tomography for detection of Frontotemporal dementia in people with suspected dementia
Imaging for the exclusion of pulmonary embolism in pregnancy
Screening for aspiration risk associated with dysphagia in acute stroke (protocol stage)
Screening tests for active pulmonary tuberculosis in children (protocol stage)
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening
Urine tests for Down's syndrome screening
First trimester serum tests for Down's syndrome screening
First and second trimester serum tests with and without first trimester ultrasound tests for Down's syndrome screening
Search strategies to identify diagnostic accuracy studies in MEDLINE and EMBASE
Second trimester serum tests for Down's Syndrome screening
Self-report screening instruments for post-traumatic stress disorder (PTSD) in survivors of traumatic experiences (protocol stage)
Sentinel node biopsy for diagnosis of pelvic lymph node involvement in early stage cervical cancer (protocol stage)
Serological laboratory tests for diagnosis of human leptospirosis in patients presenting with clinical symptoms (protocol stage)
Serological tests for primary biliary cholangitis (protocol stage)
Symptom screening for active tuberculosis in pregnant women living with HIV (protocol stage)
Symptom- and chest-radiography screening for active pulmonary tuberculosis in HIV-negative adults and adults with unknown HIV status (protocol stage)
Symptoms, ultrasound imaging and biochemical markers alone or in combination for the diagnosis of ovarian cancer in women with symptoms suspicious of ovarian cancer (protocol stage)
Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma‑induced coagulopathy in adult trauma patients with bleeding
Tests for detecting strabismus in children aged 1 to 6 years in the community
Optic nerve head and fibre layer imaging for diagnosing glaucoma
Tests for screening for hearing loss in children about to start school (protocol stage)
Tests to assist in the staging of cutaneous squamous cell carcinoma: a generic protocol (protocol stage)
Tests to detect and inform the diagnosis of caries (protocol stage)
Rapid diagnostic tests for typhoid and paratyphoid (enteric) fever
Dimercaptosuccinic acid scan or ultrasound in screening for vesicoureteral reflux among children with urinary tract infections
Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults
GenoType MTBDRassay for resistance to second-line anti-tuberculosis drugs
Computed tomography (CT) angiography for confirmation of the clinical diagnosis of brain death
Transabdominal ultrasound and endoscopic ultrasound for diagnosis of gallbladder polyps
Transcranial Doppler sonography for detecting stenosis or occlusion of intracranial arteries in people with acute ischaemic stroke
Transcutaneous bilirubinometry versus total serum bilirubin measurement for newborns (protocol stage)
Transient elastography for diagnosis of stages of hepatic fibrosis and cirrhosis in people with alcoholic liver disease
Transient ultrasound elastography and magnetic resonance elastography for the diagnosis of oesophageal varices in patients with chronic liver disease or portal vein thrombosis (protocol stage)
Ultrasonography for clinically suspected upper extremity deep vein thrombosis (protocol stage)
Ultrasonography for diagnosis of acute appendicitis (protocol stage)
Ultrasonography for endoleak detection after endoluminal abdominal aortic aneurysm repair
Ultrasound versus liver function tests for diagnosis of common bile duct stones
Ultrasound for diagnosis of birth weight discordance in twin pregnancies
Diagnostic accuracy of endoscopic ultrasonography (EUS) for the preoperative locoregional staging of primary gastric cancer
Ultrasonography for confirmation of gastric tube placement
Urinary biomarkers for the non-invasive diagnosis of endometriosis
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the early diagnosis of dementia across a variety of healthcare settings
Rapid point of care test for detecting urogenital infection in nonpregnant women and men at reproductive age
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions
Antibody tests for identification of current and past infection with SARS-CoV-2
Computer-assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults
Diagnostic accuracy of laparoscopy following computed tomography (CT) scanning for assessing the resectability with curative intent in pancreatic and periampullary cancer
Optical coherence tomography for diagnosing skin cancer in adults
Reflectance confocal microscopy for diagnosing keratinocyte skin cancers in adults
Teledermatology for diagnosing skin cancer in adults
Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults
Rapid antigen detection test for group A streptococcus in children with pharyngitis
Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children
Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis
123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma
F-FDG PET for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI)